fixed, or variable-slope sigmoidal dose-response computer model prism Search Results


dose-response smart protocol  (Promega)
90
Promega dose-response smart protocol
Dose Response Smart Protocol, supplied by Promega, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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remdesivir dose response  (Gilead Sciences)
99
Gilead Sciences remdesivir dose response
Figure 1. The interaction landscapes of the <t>remdesivir–nirmatrelvir</t> combination after 48 h (A) and 72 h (B) of incubation. A Vero E6 cell-based infection assay was used to investigate the in vitro activity of the combination. All experiments were performed using a 20A.EU1 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) strain. After the incubation, a viability assay was performed. To test whether the drug combinations act synergistically, the Highest Single Agent (HSA) reference model was calculated. An HSA score > 10 is considered synergic. Data are from 3 independent experiments performed in triplicate. Both panels (A,B) show, in order, numerical values across the matrices, synergy map and 3D plot.
Remdesivir Dose Response, supplied by Gilead Sciences, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fixed%2C+or+variable-slope+sigmoidal+dose-response+computer+model+prism/VEKLURY/pm37515263-84-20-20
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celltiter-glo assay  (Promega)
90
Promega celltiter-glo assay
Figure 1. The interaction landscapes of the <t>remdesivir–nirmatrelvir</t> combination after 48 h (A) and 72 h (B) of incubation. A Vero E6 cell-based infection assay was used to investigate the in vitro activity of the combination. All experiments were performed using a 20A.EU1 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) strain. After the incubation, a viability assay was performed. To test whether the drug combinations act synergistically, the Highest Single Agent (HSA) reference model was calculated. An HSA score > 10 is considered synergic. Data are from 3 independent experiments performed in triplicate. Both panels (A,B) show, in order, numerical values across the matrices, synergy map and 3D plot.
Celltiter Glo Assay, supplied by Promega, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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candida albicans berkhout  (ATCC)
99
ATCC candida albicans berkhout
Figure 1. The interaction landscapes of the <t>remdesivir–nirmatrelvir</t> combination after 48 h (A) and 72 h (B) of incubation. A Vero E6 cell-based infection assay was used to investigate the in vitro activity of the combination. All experiments were performed using a 20A.EU1 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) strain. After the incubation, a viability assay was performed. To test whether the drug combinations act synergistically, the Highest Single Agent (HSA) reference model was calculated. An HSA score > 10 is considered synergic. Data are from 3 independent experiments performed in triplicate. Both panels (A,B) show, in order, numerical values across the matrices, synergy map and 3D plot.
Candida Albicans Berkhout, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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issatchenkia orientalis kudrjanzev  (ATCC)
99
ATCC issatchenkia orientalis kudrjanzev
Figure 1. The interaction landscapes of the <t>remdesivir–nirmatrelvir</t> combination after 48 h (A) and 72 h (B) of incubation. A Vero E6 cell-based infection assay was used to investigate the in vitro activity of the combination. All experiments were performed using a 20A.EU1 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) strain. After the incubation, a viability assay was performed. To test whether the drug combinations act synergistically, the Highest Single Agent (HSA) reference model was calculated. An HSA score > 10 is considered synergic. Data are from 3 independent experiments performed in triplicate. Both panels (A,B) show, in order, numerical values across the matrices, synergy map and 3D plot.
Issatchenkia Orientalis Kudrjanzev, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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bacillus spizizenii dunlap et al  (ATCC)
99
ATCC bacillus spizizenii dunlap et al
Figure 1. The interaction landscapes of the <t>remdesivir–nirmatrelvir</t> combination after 48 h (A) and 72 h (B) of incubation. A Vero E6 cell-based infection assay was used to investigate the in vitro activity of the combination. All experiments were performed using a 20A.EU1 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) strain. After the incubation, a viability assay was performed. To test whether the drug combinations act synergistically, the Highest Single Agent (HSA) reference model was calculated. An HSA score > 10 is considered synergic. Data are from 3 independent experiments performed in triplicate. Both panels (A,B) show, in order, numerical values across the matrices, synergy map and 3D plot.
Bacillus Spizizenii Dunlap Et Al, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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bacillus spizizenii dunlap et al - by Bioz Stars, 2026-09
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camp-glo assay kit  (Promega)
90
Promega camp-glo assay kit
Figure 1. The interaction landscapes of the <t>remdesivir–nirmatrelvir</t> combination after 48 h (A) and 72 h (B) of incubation. A Vero E6 cell-based infection assay was used to investigate the in vitro activity of the combination. All experiments were performed using a 20A.EU1 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) strain. After the incubation, a viability assay was performed. To test whether the drug combinations act synergistically, the Highest Single Agent (HSA) reference model was calculated. An HSA score > 10 is considered synergic. Data are from 3 independent experiments performed in triplicate. Both panels (A,B) show, in order, numerical values across the matrices, synergy map and 3D plot.
Camp Glo Assay Kit, supplied by Promega, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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camp-glo assay kit - by Bioz Stars, 2026-09
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escherichia coli castellani and chalmers  (ATCC)
99
ATCC escherichia coli castellani and chalmers
Figure 1. The interaction landscapes of the <t>remdesivir–nirmatrelvir</t> combination after 48 h (A) and 72 h (B) of incubation. A Vero E6 cell-based infection assay was used to investigate the in vitro activity of the combination. All experiments were performed using a 20A.EU1 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) strain. After the incubation, a viability assay was performed. To test whether the drug combinations act synergistically, the Highest Single Agent (HSA) reference model was calculated. An HSA score > 10 is considered synergic. Data are from 3 independent experiments performed in triplicate. Both panels (A,B) show, in order, numerical values across the matrices, synergy map and 3D plot.
Escherichia Coli Castellani And Chalmers, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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nonlinear fit originlab version 2018  (OriginLab corp)
90
OriginLab corp nonlinear fit originlab version 2018
Figure 1. The interaction landscapes of the <t>remdesivir–nirmatrelvir</t> combination after 48 h (A) and 72 h (B) of incubation. A Vero E6 cell-based infection assay was used to investigate the in vitro activity of the combination. All experiments were performed using a 20A.EU1 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) strain. After the incubation, a viability assay was performed. To test whether the drug combinations act synergistically, the Highest Single Agent (HSA) reference model was calculated. An HSA score > 10 is considered synergic. Data are from 3 independent experiments performed in triplicate. Both panels (A,B) show, in order, numerical values across the matrices, synergy map and 3D plot.
Nonlinear Fit Originlab Version 2018, supplied by OriginLab corp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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nonlinear fit originlab version 2018 - by Bioz Stars, 2026-09
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tecan spark instrument  (Tecan Systems)
99
Tecan Systems tecan spark instrument
Figure 1. The interaction landscapes of the <t>remdesivir–nirmatrelvir</t> combination after 48 h (A) and 72 h (B) of incubation. A Vero E6 cell-based infection assay was used to investigate the in vitro activity of the combination. All experiments were performed using a 20A.EU1 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) strain. After the incubation, a viability assay was performed. To test whether the drug combinations act synergistically, the Highest Single Agent (HSA) reference model was calculated. An HSA score > 10 is considered synergic. Data are from 3 independent experiments performed in triplicate. Both panels (A,B) show, in order, numerical values across the matrices, synergy map and 3D plot.
Tecan Spark Instrument, supplied by Tecan Systems, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 99 stars, based on 1 article reviews
tecan spark instrument - by Bioz Stars, 2026-09
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camp-glo™ assay  (Promega)
90
Promega camp-glo™ assay
Figure 1. The interaction landscapes of the <t>remdesivir–nirmatrelvir</t> combination after 48 h (A) and 72 h (B) of incubation. A Vero E6 cell-based infection assay was used to investigate the in vitro activity of the combination. All experiments were performed using a 20A.EU1 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) strain. After the incubation, a viability assay was performed. To test whether the drug combinations act synergistically, the Highest Single Agent (HSA) reference model was calculated. An HSA score > 10 is considered synergic. Data are from 3 independent experiments performed in triplicate. Both panels (A,B) show, in order, numerical values across the matrices, synergy map and 3D plot.
Camp Glo™ Assay, supplied by Promega, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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camp-glo™ assay - by Bioz Stars, 2026-09
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facscanto-ii  (Becton Dickinson)
90
Becton Dickinson facscanto-ii
Figure 1. The interaction landscapes of the <t>remdesivir–nirmatrelvir</t> combination after 48 h (A) and 72 h (B) of incubation. A Vero E6 cell-based infection assay was used to investigate the in vitro activity of the combination. All experiments were performed using a 20A.EU1 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) strain. After the incubation, a viability assay was performed. To test whether the drug combinations act synergistically, the Highest Single Agent (HSA) reference model was calculated. An HSA score > 10 is considered synergic. Data are from 3 independent experiments performed in triplicate. Both panels (A,B) show, in order, numerical values across the matrices, synergy map and 3D plot.
Facscanto Ii, supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Figure 1. The interaction landscapes of the remdesivir–nirmatrelvir combination after 48 h (A) and 72 h (B) of incubation. A Vero E6 cell-based infection assay was used to investigate the in vitro activity of the combination. All experiments were performed using a 20A.EU1 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) strain. After the incubation, a viability assay was performed. To test whether the drug combinations act synergistically, the Highest Single Agent (HSA) reference model was calculated. An HSA score > 10 is considered synergic. Data are from 3 independent experiments performed in triplicate. Both panels (A,B) show, in order, numerical values across the matrices, synergy map and 3D plot.

Journal: Viruses

Article Title: Synergistic Activity of Remdesivir-Nirmatrelvir Combination on a SARS-CoV-2 In Vitro Model and a Case Report.

doi: 10.3390/v15071577

Figure Lengend Snippet: Figure 1. The interaction landscapes of the remdesivir–nirmatrelvir combination after 48 h (A) and 72 h (B) of incubation. A Vero E6 cell-based infection assay was used to investigate the in vitro activity of the combination. All experiments were performed using a 20A.EU1 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) strain. After the incubation, a viability assay was performed. To test whether the drug combinations act synergistically, the Highest Single Agent (HSA) reference model was calculated. An HSA score > 10 is considered synergic. Data are from 3 independent experiments performed in triplicate. Both panels (A,B) show, in order, numerical values across the matrices, synergy map and 3D plot.

Article Snippet: Remdesivir antiviral activity was tested in vitro with a Vero E6 cell-based viability model. Four-parameter variable slope regression modelling of remdesivir dose–response showed an EC50 of 1.2 μM (95% confidence interval, CI, 0.6–2.4) and an EC90 of 5.7 μM with a slope of 1.4 (95% CI 0.6–4.8) after 48 h of treatment (Supplementary Figure S1A).

Techniques: Incubation, Infection, In Vitro, Activity Assay, Viability Assay